Abstract | BACKGROUND: OBJECTIVE: The objective of this study was to investigate the association of IGF-1 and IGFBP-3 levels with prevalent and incident AF in a large population-based study. METHODS: Data from the Study of Health in Pomerania (SHIP) were collected. At presentation, a medical examination, standardized electrocardiographic assessment, and measurements of serum IGF-1 and IGFBP-3 levels were performed. Incident AF was assessed in individuals without AF at baseline (SHIP-1) who developed AF during follow-up (SHIP-2; after a mean of 5.2 years). RESULTS: Of 3160 participants, 66 (2.1%) exhibited AF at baseline. IGF-1 levels and IGF-1/ IGFBP-3 ratios were significantly lower in individuals with AF than in those without AF (IGF-1: 104.2 ± 41.6 ng/mL vs 142.9 ± 53.5 ng/mL, P < .001 and IGF-1/ IGFBP-3: 0.031 ± (0.009 ng/mL vs 0.036 ± 0.010 ng/mL, P = .006, respectively). Multivariable-adjusted logistic regression models showed that a low IGF-1/ IGFBP-3 ratio was associated with prevalent AF (odds ratios 0.67; 95% confidence interval 0.48-0.94; P = .021). Of 1817 individuals without AF at baseline, 27 (1.5%) developed AF during follow-up. In these participants, IGF-1 levels, but not IGF-1/ IGFBP-3 ratios, were significantly lower (IGF-1: 113.3 ± 38.6 ng/mL vs 147.2 ± 51.6 ng/mL, P = .013 and IGF-1/ IGFBP-3: 0.033 ± 0.008 ng/mL vs 0.036 ± 0.010 ng/mL, P = .176). CONCLUSION: Low IGF-1/ IGFBP-3 ratios are associated with a higher prevalence of AF. There seems to be a similar impact in incident AF.
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Authors | Mathias Busch, Anne Krüger, Stefan Gross, Till Ittermann, Nele Friedrich, Matthias Nauck, Marcus Dörr, Stephan B Felix |
Journal | Heart rhythm
(Heart Rhythm)
Vol. 16
Issue 9
Pg. 1314-1319
(09 2019)
ISSN: 1556-3871 [Electronic] United States |
PMID | 30910708
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- IGF1 protein, human
- IGFBP3 protein, human
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
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Topics |
- Atrial Fibrillation
(blood, diagnosis, epidemiology)
- Cohort Studies
- Electrocardiography
(methods, statistics & numerical data)
- Female
- Germany
(epidemiology)
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(analysis)
- Insulin-Like Growth Factor I
(analysis)
- Male
- Middle Aged
- Odds Ratio
- Prevalence
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