Angong Niuhuang Pill as adjuvant therapy for treating acute cerebral infarction and intracerebral hemorrhage: A meta-analysis of randomized controlled trials.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Angong Niuhuang Pill (ANP) is a well-known traditional Chinese patent medicine. This meta-analysis aimed to evaluate the efficacy and safety of ANP as an adjuvant therapy in patients with acute cerebral infarction (ACI) and acute intracerebral hemorrhage (AIH).

MATERIALS AND METHODS:

We performed a literature search in Embase, Pubmed, Cochrane Library, CNKI, Wanfang, and VIP database from their inceptions to April 2018. Randomized controlled trials evaluating ANP as an adjuvant therapy for acute stroke were selected. Risk ratio (RR) or weighted mean difference (WMD) with their 95% confidence interval (CI) was calculated between with and without ANP therapy.

RESULTS:

Eighteen trials involving 1,601 patients were identified and analyzed. Meta-analysis showed that ANP plus usual treatment significantly improved the total response rate in patients with ACI (RR 1.27; 95% CI 1.14-1.41) and AIH (RR 1.26; 95% CI 1.14-1.38) compared with the usual treatment alone. Adjuvant treatment with ANP also significantly reduced the neurologic deficit score in patients with ACI (WMD -3.64; 95% CI -4.97 to - 2.31) and AIH (WMD -3.52; 95% CI -5.51 to -1.54). Moreover, ANP significantly improved the Glasgow Coma Scale in patients with ACI (WMD 1.18; 95% CI 0.79-1.56) and AIH (WMD 2.28; 95% CI 1.37-3.19).

CONCLUSIONS:

Adjuvant treatment with ANP appears to improve the total response rate and neurologic deficit score in patients with ACI and AIH. More well-designed trials are required due to the suboptimal methodological quality of the included trials.

• Authors: Hanwei Liu, Yan Yan, Pengfei Pang, Junjie Mao, Xiaojun Hu, Dan Li, Bin Zhou, Hong Shan
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 237 Pg. 307-313 (Jun 12 2019) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 30910581 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Angong Niuhuang Pill
• Drugs, Chinese Herbal

Topics

• Cerebral Hemorrhage (drug therapy)
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Randomized Controlled Trials as Topic
• Stroke (drug therapy)