Heart myxoma develops oncogenic and metastatic phenotype.

Abstract

PURPOSE:

Heart myxomas have been frequently considered as benign lesions associated with Carney's complex. However, after surgical removal, myxomas re-emerge causing dysfunctional heart.

METHODS:

To identify whether cardiac myxomas may develop a metastatic phenotype as occurs in malignant cancers, a profile of several proteins involved in malignancy such as oncogenes (c-MYC, K-RAS and H-RAS), cancer-associated metabolic transcriptional factors (HIF-1α, p53 and PPAR-γ) and epithelial-mesenchymal transition proteins (fibronectin, vimentin, β-catenin, SNAIL and MMP-9) were evaluated in seven samples from a cohort of patients with atrial and ventricular myxomas. The analysis was also performed in: (1) cardiac tissue surrounding the area where myxoma was removed; (2) non-cancer heart tissue (NCHT); and (3) malignant triple negative breast cancer biopsies for comparative purposes.

RESULTS:

Statistical analysis applying univariate (Kruskal-Wallis and Dunn's tests) and multivariate analyses (PCA, principal component analysis) revealed that heart myxomas (7-15 times) and myxoma surrounding tissue (22-99 times) vs. NCHT showed high content of c-MYC, p53, vimentin, and HIF-1α, indicating that both myxoma and its surrounding area express oncogenes and malignancy-related proteins as occurs in triple negative breast cancer.

CONCLUSIONS:

Based on ROC (receiver operating characteristics) statistical analysis, c-MYC, HIF-1α, p53, and vimentin may be considered potential biomarkers for malignancy detection in myxoma.

• Authors: Silvia Cecilia Pacheco-Velázquez, Juan Carlos Gallardo-Pérez, Daniel Díaz, Alhelí Adán-Ladrón de Guevara, Diana Xochiquetzal Robledo-Cadena, Emma Saavedra, Luz Ruiz-Godoy, Luis Roberto Jimenez-Hernández, Jesús Vargas-Barrón, José Luis Aguilar-Ponce, Sara Rodríguez-Enríquez
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 145 Issue 5 Pg. 1283-1295 (May 2019) ISSN: 1432-1335 [Electronic] Germany
• PMID: 30900156 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Proteome

Topics

• Animals
• Biomarkers, Tumor
• Cell Transformation, Neoplastic
• Echocardiography
• Heart Neoplasms (diagnostic imaging, etiology, pathology)
• Humans
• Myxoma (diagnostic imaging, etiology, pathology)
• Neoplasm Grading
• Neoplasm Metastasis
• Neoplasm Staging
• Oncogenes
• Phenotype
• Proteome
• Proteomics (methods)
• ROC Curve
• Rats