BACKGROUND Our research was designed to investigate the relationship of
spleen tyrosine kinase (Syk) and inflammatory factors with
coronary heart disease (CHD) and the risk factors of CHD. MATERIAL AND METHODS In our study, 226 patients were enrolled, from October 2017 to March 2018. Clinical and biochemical data were collected. We collected samples of peripheral blood monocytes (PBMs) from the enrolled patients. The patients were divided in 4 groups: patients without
coronary artery disease (control group), patients with
stable angina pectoris (SAP group), patients with non-ST-segment elevation
acute coronary syndrome (NSTE-ACS group), and patients with ST-segment elevation acute
myocardial infarction group (
STEMI group). We detect the
protein levels of Syk and inflammatory factors expression by western blot. RESULTS Our results found the
protein levels of Syk and inflammatory factors expression in the NSTE-ACS and
STEMI groups were higher than those in the SAP and control groups. The
protein levels of Syk and inflammatory factors expression in the SAP group were higher than those in the control group. Moreover, there were many risk factors significantly associated with Syk. Besides that, these risk factors were also independent risk factors of CHD. CONCLUSIONS Our results found that the level of Syk was associated with the severity of CHD. From our study, we found that higher levels of Syk and inflammatory factors
protein were associated with worse results of the CHD. For the first time, Syk was reported to be a promising therapeutic factor for CHD patients.