Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population.

Abstract

The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case-control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.

• Authors: Lun Liu, Jie Zheng, Yajing Xu, Jian Gao, Lingling Fan, Dong Xu
• Journal: Bioscience reports (Biosci Rep) Vol. 39 Issue 4 (04 30 2019) ISSN: 1573-4935 [Electronic] England
• PMID: 30890581 (Publication Type: Journal Article)
• Copyright: © 2019 The Author(s).

Chemical References

• IL10 protein, human
• Interleukin-10

Topics

• Adult
• Aged
• Asian People (genetics)
• Case-Control Studies
• China (epidemiology)
• Diabetes Mellitus, Type 2 (epidemiology, genetics)
• Diabetic Retinopathy (epidemiology, genetics)
• Female
• Humans
• Interleukin-10 (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Protective Factors