The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children.

Abstract

The aim of the present study was to investigate hair essential trace elements and mineral levels in 105 pregnant normal-weight (control) and 55 overweight and obese women in the third trimester of pregnancy, as well as in their children at the age of 9 months. The hair essential trace elements and mineral levels were assessed using inductively coupled plasma mass-spectrometry. Overweight pregnant women had significantly reduced Cr (- 24%; p = 0.047) and Zn (- 13%; p = 0.008) content, as well as elevated hair Na and K levels as compared to the controls. Children from overweight and obese mothers had lower hair Mo (- 18%; p = 0.017), Se (- 8%; p = 0.043), and V (- 24%; p = 0.028) levels, as well as elevated Sr content (19%; p = 0.025). Correlation analysis revealed a significant relationship between maternal and child hair levels of Co (r = 0.170; p = 0.038), Cu (r = 0.513; p < 0.001), Mn (r = 0.240; p = 0.003), and Na (r = 0.181; p = 0.027) in the whole sample. Pre-pregnancy maternal body mass index (BMI) positively correlated with maternal hair K (r = 0.336; p < 0.001) and Na (r = 0.212; p = 0.008) and negatively correlated with V (r = - 0.204; p = 0.011) and Zn (r = - 0.162; p = 0.045) levels. The results indicate that impaired trace element and mineral metabolism may play a role in the link between maternal obesity, complications of pregnancy and child's postnatal development. Hypothetically, dietary improvement may be used as a tool to reduce these risks. However, further experimental and clinical studies are required to investigate the relationship between obesity and trace element metabolism in pregnancy.

• Authors: Anatoly V Skalny, Alexey A Tinkov, Tatiana G Bohan, Marina B Shabalovskaya, Olga Terekhina, Svetlana B Leshchinskaia, Lyubov A Agarkova, Svetlana V Notova, Margarita G Skalnaya, Yulia Kovas
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 193 Issue 1 Pg. 64-72 (Jan 2020) ISSN: 1559-0720 [Electronic] United States
• PMID: 30887283 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Trace Elements

Topics

• Adult
• Body Mass Index
• Child, Preschool
• Female
• Hair (metabolism)
• Humans
• Infant
• Infant, Newborn
• Male
• Obesity, Maternal (blood)
• Pregnancy
• Siberia
• Trace Elements (blood)