Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment.

Abstract

Purpose: To define the actions of boron on normal neurophysiology and glioblastoma growth. Materials and Methods: PubMed and other relevant databases were searched. Results: Discovery of novel boron compounds in treatment of glioblastoma is being actively investigated, but the majority of such studies is focused on the synthesis of boron compounds as sensitizers to Boron Neutron Capture Therapy (BNCT). Nonetheless, the translational functionality of boron compounds is not limited to BNCT as many boron compounds possess direct tumoricidal activity and there is substantial evidence that certain boron compounds can cross the blood-brain barrier. Moreover, boron-containing compounds interfere with several tumorigenic pathways including intratumoral IGF-I levels, molybdenum Fe-S containing flavin hydroxylases, glycolysis, Transient Receptor Potential (TRP) and Store Operated Calcium Entry (SOCE) channels. Conclusions: Boron compounds deserve to be studied further in treatment of systemic cancers and glioblastoma due to their versatile antineoplastic functions.

• Authors: Meric A Altinoz, Gulacti Topcu, İlhan Elmaci
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 129 Issue 10 Pg. 963-977 (Oct 2019) ISSN: 1563-5279 [Electronic] England
• PMID: 30885023 (Publication Type: Journal Article, Review)

Chemical References

• Boron Compounds
• Boron

Topics

• Animals
• Boron (metabolism, pharmacology, therapeutic use)
• Boron Compounds (metabolism, pharmacology, therapeutic use)
• Boron Neutron Capture Therapy (methods, trends)
• Brain (drug effects, metabolism)
• Brain Neoplasms (drug therapy, metabolism, radiotherapy)
• Glioblastoma (drug therapy, metabolism, radiotherapy)
• Humans
• Treatment Outcome