Boron

A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.

Also Known As:

Networked: 1238 relevant articles (76 outcomes, 217 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Suzuki, Minoru: 35 articles (09/2022 - 05/2004)
2.	Ono, Koji: 34 articles (09/2022 - 05/2004)
3.	Barth, Rolf F: 28 articles (06/2020 - 03/2002)
4.	Nakamura, Hiroyuki: 24 articles (06/2022 - 03/2002)
5.	Sakurai, Yoshinori: 20 articles (11/2021 - 05/2004)
6.	Yang, Weilian: 19 articles (01/2018 - 03/2002)
7.	Kawabata, Shinji: 18 articles (01/2022 - 12/2005)
8.	Schwint, Amanda E: 18 articles (01/2019 - 03/2003)
9.	Kirihata, Mitsunori: 17 articles (01/2022 - 12/2005)
10.	Trivillin, Verónica A: 17 articles (01/2019 - 11/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2014 - "This study demonstrated that pulsed-HIFU was beneficial to the accumulation of boron drug in the head and neck tumor lesion and may enhance the therapeutic efficacy of clinical BNCT." 08/01/2022 - "The structural similarity, peak signal-to-noise ratio, and root mean square error of the images generated by the trained network are improved significantly, and the ratio of the boron concentration between the tumor area and the normal tissue is improved from 1.55 to 3.85, which is much closer to the true value of 3.52. " 02/01/1995 - "A selective boron delivery to the neoplasm is a prerequisite for successful therapy. " 06/01/2005 - "Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor boron content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy. " 11/01/2022 - "One step synthesis of 10B-enriched 10BPO4 nanoparticles for effective boron neutron capture therapeutic treatment of recurrent head-and-neck tumor."
2.	Glioma (Gliomas) 04/01/2000 - "These results demonstrate that using a combination of boron agents and optimizing their delivery can dramatically improve the efficacy of BNCT in glioma-bearing rats." 02/01/1993 - "In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. " 06/01/2011 - "Second, to determine the efficacy of H2TCP and H2TBP as boron delivery agents for BNCT in F98 glioma bearing rats. " 09/15/2023 - "This study evaluated the use of boron-conjugated 4-iodophenylbutanamide (BC-IP), a novel boron compound in BNCT, for the treatment of glioma. " 06/23/2021 - "This study evaluated the boron concentration in intracranial grafts of human glioma U87MG cells and normal tissues of the brain and other organs of mice at 1, 2.5 and 5 h after administration of the boron-carrying compounds. "
3.	Brain Neoplasms (Brain Tumor) 11/01/2022 - "To improve the therapeutic efficacy of BNCT for brain tumors, we developed a boron delivery system that involves the cerebrospinal fluid (CSF), in contrast to the conventional method that involves intravenous (IV) administration. " 07/01/2000 - "The MEPHISTO spectromicroscope, which performs microchemical analysis by x-ray absorption near edge structure (XANES) spectroscopy from microscopic areas, has been used to study the distribution of trace quantities of boron in human brain cancer tissues surgically removed from patients first administered with the compound Na2B12H11SH (BSH). " 07/01/1999 - "The boron concentration was measured by an in vivo rat experimental brain tumor model and an in vitro cell culture study. " 02/27/2023 - "In biodistribution experiments, cRGD-MID-AC accumulated in the brain tumor, with the highest boron concentration observed 8 h after administration. " 11/04/2022 - "Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats-Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging."
4.	Glioblastoma (Glioblastoma Multiforme) 03/01/2005 - "This enhancement is estimated assuming currently achievable boron concentrations, and is more than adequate to provide a therapeutic window for the effective treatment of Glioblastoma Multiforme without prohibitive toxicity to the normal brain." 07/07/2021 - "This study represents the first example of using 2'-F-RNA aptamer GL44 specific to the human glioblastoma U-87 MG cells as a boron delivery agent for BNCT. " 07/01/2009 - "To study subcellular delivery of boron from ABCPC in T98G human glioblastoma cells, we employed secondary ion mass spectrometry (SIMS) based technique of ion microscopy, which is capable of quantitatively imaging isotopic (elemental) gradients in cells and tissues at 500 nm spatial resolution. " 03/01/2003 - "Five patients suffering from glioblastoma multiforme and treated with BNCT in a dose escalation study were administered the boron compound, boron sulfhydryl (BSH; Na(2)B(12)H(11)SH). " 03/30/1994 - "Twenty four patients suffering from a glioblastoma multiforme entered the study to date, infused with a maximum concentration of up to 50 mg BSH/kg. Boron concentration measurements in tissues, urine, and blood were carried out, using inductively coupled plasma-atomic spectroscopy (ICP-AES) and quantitative neutron capture radiography (QNCR). "
5.	Melanoma (Melanoma, Malignant) 01/01/2013 - "Both in vivo and in vitro studies in melanoma models demonstrated that boron was localized in the cytoplasm and nuclei with some cell-to-cell variability. " 06/01/1994 - "This note reports on the study of the boron distribution in tissues on an animal model (nude mice) xenografted with a human ocular melanoma after an i.p.injection of 2g/kg of 10B-BPA and in cells cultured in the presence of 530 mumol/l of 10B-BPA. " 07/01/1989 - "Preclinical studies in animals show that several MAbs may bind to melanoma cells in sufficient quantities in vitro to localize the required amount of Boron per cell. " 02/01/1989 - "In vitro and in vivo studies of boron conjugated melanoma affined biochemicals." 03/03/2022 - "Second, we measured and compared the boron concentration in the melanoma model rats after administering boron via either the CSF administration method or the intravenous (IV) administration method, with estimation of the T/N ratio. "

Related Drugs and Biologics

1.	Gadolinium
2.	Liposomes (Liposome)
3.	Sodium
4.	Boron Compounds
5.	Proteins (Proteins, Gene)
6.	Molybdenum
7.	tavaborole
8.	Phenylalanine (L-Phenylalanine)
9.	Selenium
10.	Zinc

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy
2.	Therapeutics
3.	Neutron Capture Therapy
4.	Precision Medicine
5.	Radiotherapy