Abstract | AIMS: METHODS: MEDLINE, EMBASE, and the ISI Web of Science were searched for all eligible published studies concerning the relationship of ACE gene polymorphism with AS without language restrictions. Pooled odds ratios ( ORs) with 95% confidence intervals (CIs) were calculated to evaluate this relationship under different genetic models using meta-analytic methods. RESULTS: A total of 15 articles (16 studies) were involved in this meta-analysis. The D allele of the ACE gene had a nonsignificant increase in the risk of AS (D versus I: OR = 1.23, 95% CI, .98-1.53, P = .07; I2 = 87.2%, Pheterogeneity < .01). Compared with the II genotype, the DI (relative risk [RR]: 1.35, 95% CI: 1.09, 1.67, P < .01; I2 = 47.8%, Pheterogeneity = .017) and (DD + DI) (RR = 1.38, 95% CI: 1.04, 1.82, P = .02; I2 = 73.3%, Pheterogeneity < .01) genotype of ACE was associated with higher risk of AS, respectively. Subjects with the DD genotype showed a statistically nonsignificant trend toward greater risk of AS (RR = 1.53, 95% CI: .97, 2.43, P = .07; I2 = 88.6%, Pheterogeneity < .01). Further subgroup analyses showed that significant relationships were only found in Europeans under different gene polymorphism or different genotype models rather than Asians. CONCLUSIONS: The present meta-analysis indicated that the D allele in the ACE gene was associated with the risk of AS, especially in Europeans. Furthermore, increased copy number of D allele was significantly associated with increased AS risk in a dose-dependent manner.
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Authors | Man-Man Xia, Mingxu Wang, Hong Jiang, Yan Liu, Le Ma, Chao Lu, Wei Zhang |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 28
Issue 6
Pg. 1732-1743
(Jun 2019)
ISSN: 1532-8511 [Electronic] United States |
PMID | 30878369
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- ACE protein, human
- Peptidyl-Dipeptidase A
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Topics |
- Adult
- Aged
- Atherosclerosis
(diagnosis, enzymology, ethnology, genetics)
- DNA Copy Number Variations
- Female
- Gene Dosage
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- INDEL Mutation
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(genetics)
- Phenotype
- Polymorphism, Genetic
- Prognosis
- Risk Assessment
- Risk Factors
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