Mortality associated with statins in men with advanced prostate cancer treated with androgen deprivation therapy.

Abstract

OBJECTIVES:

Before launching large clinical trials to confirm the effects of statins in improving outcomes among men with prostate cancer (PC), the most appropriate target patient population and the type of statins need to be clearly identified.

PATIENTS AND METHODS:

A retrospective cohort study was conducted using the Taiwan Cancer Registry of 2008-2014. This study included 5749 men with locally advanced and metastatic PC who received only androgen deprivation therapy (ADT) in the first year after their cancer diagnosis. Statin users were defined as anyone who was prescribed statins for >28 days. An inverse probability of treatment-weighted Cox model was used to estimate the effects of statin use on all-cause mortality and PC-specific mortality (PCSM) while treating the statin status as a time-dependent variable.

RESULTS:

Overall, 2259 patients died, and 1495 of them died of PC during a median follow-up of 3.6 years from 1 year after their diagnosis. Statin use was associated with significant reductions in all-cause mortality (hazard ratio [HR] = 0.78, 95% confidence interval [CI]: 0.70-0.86) and PCSM (HR = 0.76, 95% CI: 0.68-0.86) for metastatic disease and all-cause mortality (HR = 0.66, 95% CI: 0.54-0.81) for locally advanced disease. Patients who received atorvastatin, pravastatin, rosuvastatin or pitavastatin showed a stronger reduction in mortality than those who received other statins. Benefits of statins were consistently observed in men who received post-diagnostic statins, even in those with high comorbidities or an old age.

CONCLUSIONS:

Our results suggest that only atorvastatin, pravastatin and rosuvastatin were associated with improved survival in advanced PC patients receiving ADT.

• Authors: Szu-Yuan Wu, Su-Chen Fang, Hung-Jen Shih, Yu-Chin Wen, Yu-Hsuan Joni Shao
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 112 Pg. 109-117 (05 2019) ISSN: 1879-0852 [Electronic] England
• PMID: 30827745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Androgen Antagonists
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Topics

• Aged
• Androgen Antagonists (therapeutic use)
• Cause of Death
• Disease Progression
• Follow-Up Studies
• Hormone Replacement Therapy (methods)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Male
• Proportional Hazards Models
• Prostatic Neoplasms (drug therapy, mortality)
• Retrospective Studies
• Taiwan