Anti-inflammatory cytokines in endometriosis.

Abstract

Although the pathogenesis of endometriosis is not fully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-β1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.

• Authors: Wen-Jie Zhou, Hui-Li Yang, Jun Shao, Jie Mei, Kai-Kai Chang, Rui Zhu, Ming-Qing Li
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 76 Issue 11 Pg. 2111-2132 (Jun 2019) ISSN: 1420-9071 [Electronic] Switzerland
• PMID: 30826860 (Publication Type: Journal Article, Review)

Chemical References

• IL10 protein, human
• IL4 protein, human
• TGFB1 protein, human
• Transforming Growth Factor beta1
• Interleukin-10
• Interleukin-4

Topics

• Disease Progression
• Endometriosis (genetics, immunology, pathology)
• Endometrium (immunology, pathology)
• Epithelial Cells (immunology, pathology)
• Epithelial-Mesenchymal Transition (genetics, immunology)
• Female
• Gene Expression Regulation
• Humans
• Inflammation
• Interleukin-10 (genetics, immunology)
• Interleukin-4 (genetics, immunology)
• Killer Cells, Natural (immunology, pathology)
• Macrophages (immunology, pathology)
• Signal Transduction
• Stromal Cells (immunology, pathology)
• T-Lymphocytes (immunology, pathology)
• Transforming Growth Factor beta1 (genetics, immunology)