Efficacy of topical clotrimazole vs. topical tolnaftate in the treatment of otomycosis. A randomized controlled clinical trial.

Abstract

INTRODUCTION:

Otomycosis, an infection of the ear canal by fungi, is prevalent in hot and humid weather. Nevertheless, there is not sufficient evidence for the effectiveness of different topical antifungal treatments. Tolnaftate, is a topical antifungal agent described to be effective in the treatment of otomycosis. Currently there are not sufficient studies that prove its efficacy.

OBJECTIVES:

To compare the efficacy of clotrimazole and tolnaftate administration in the treatment of otomycosis.

MATERIAL AND METHODS:

A controlled, randomized and open clinical trial included patients diagnosed with fungal external otitis who were treated with topical antifungals, randomized into two treatment groups: (1) clotrimazole cream; (2) tolnaftate solution. They were microscopically evaluated at one and two weeks of treatment to determine resolution of disease. Recurrence and complications were recorded. Demographic and clinical variables were collected and analyzed. Follow-up and final outcomes (absence of infection) were compared between groups.

RESULTS:

Forty eight patients were included, 28 in the clotrimazole group and 20 in the tolnaftate group. Spring was the weather most commonly associated with otomycosis, while otic manipulation was the risk factor more common in both groups. Predominant symptoms were itching and otic fullness. Aspergillus niger organism was isolated most frequently. Treatment with clotrimazole resulted in 75% resolution vs 45% resolution with treatment with tolnaftate at one week of treatment (p=0.007). The Tolnaftate treatment group demonstrated higher recurrence rates and treatment failures, 20% and 15% respectively.

CONCLUSIONS:

Clotrimazole cream treatment is more effective than tolnaftate for uncomplicated otomycosis. More studies are needed to corroborate our results.

• Authors: Lesly Jimenez-Garcia, Erika Celis-Aguilar, Gaudencio Díaz-Pavón, Victor Muñoz Estrada, Ángel Castro-Urquizo, Nemiliztli Hernández-Castillo, Ernesto Amaro-Flores
• Journal: Brazilian journal of otorhinolaryngology (Braz J Otorhinolaryngol) 2020 May - Jun Vol. 86 Issue 3 Pg. 300-307 ISSN: 1808-8686 [Electronic] Brazil
• PMID: 30826311 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

Chemical References

• Antifungal Agents
• Tolnaftate
• Clotrimazole

Topics

• Adolescent
• Adult
• Aged
• Antifungal Agents (administration & dosage)
• Child
• Clotrimazole (administration & dosage)
• Female
• Humans
• Male
• Middle Aged
• Otomycosis (drug therapy, microbiology)
• Tolnaftate (administration & dosage)
• Treatment Outcome
• Young Adult