[Estradiol and progesterone receptors in DMBA-induced mammary neoplasms in rats under cyclic hormonal exposures].

Abstract

Hormones in physiological doses and under cyclic regime were injected to rats with DMBA-induced mammary tumours. It is demonstrated that 17-alpha-hydroxyprogesterone capronate (HPC) alone administered once every 6 days reduces estradiol receptor (ER) and progesterone receptor (PR) levels and the frequency of R+ tumours. Under the influence of a successive use of HPC and testosterone (TS) the level of PR and the frequency of PR+ tumours were reduced. A high level of ER and PR and a high frequency of R+ tumours were observed after a successive administration of insulin, prednisolone, HPC and TS. All the variants of hormonal influences resulted in an increased life duration of animals, a reduced growth rate, and an increased degree of mammary tumour differentiation.

• Authors: N S Kartavova, N S Gutnik, D P Burlaka, O I Dasiukevich
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 8 Issue 1 Pg. 54-8 ( 1986) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Retseptory éstradiola i progesterona v indutsirovannykh DMBA opukholiakh molochnoĭ zhelezy u krys pri tsiklicheskikh gormonal'nykh vozdeĭstviiakh.
• PMID: 3081323 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hydroxyprogesterones
• Receptors, Estradiol
• Receptors, Estrogen
• Receptors, Progesterone
• Testosterone
• 9,10-Dimethyl-1,2-benzanthracene
• 17-alpha-Hydroxyprogesterone

Topics

• 17-alpha-Hydroxyprogesterone
• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Cytosol (analysis, drug effects)
• Female
• Hydroxyprogesterones (pharmacology)
• Mammary Neoplasms, Experimental (analysis, chemically induced, mortality)
• Rats
• Receptors, Estradiol (analysis, drug effects)
• Receptors, Estrogen (drug effects)
• Receptors, Progesterone (analysis, drug effects)
• Testosterone (pharmacology)
• Time Factors