Meropenem and Amikacin for Management of Post-Neurosurgical Infections from Acinetobacter baumannii.

Abstract

Background: Intra-cranial infection with Acinetobacter baumannii is a tough problem because of the presence of multi-resistance and poor drug penetration through the blood-brain barrier. Such intra-cranial infections can lead to serious complications and death. We retrospectively analyzed the culture results and clinical characteristics of patients with intra-cranial infections in our hospital and suggested intravenous (IV) meropenem and intra-thecal (IT) amikacin therapy may be effective in the management of A. baumannii infection. Case presentation: We reported four cases of post-neuro-surgical A. baumannii intra-cranial infection whose clinical futures were high fever and consciousness disturbance. Our patients were treated successfully with IV meropenem and IT amikacin. Conclusion: We presented our cases of pandrug-resistant A. baumannii intra-cranial infection that was managed successfully with a systemic provision of IV meropenem and IT amikacin. Therefore, these cases exemplify that systemic administration of IV meropenem and IT amikacin can be a good therapeutic option against A. baumannii intra-cranial infection when colistin is not available.

• Authors: Qiang Huang, Quan Zhou, Tao Ju, Huaqiang Xu, Wenguo Wang
• Journal: Surgical infections (Surg Infect (Larchmt)) 2019 May/Jun Vol. 20 Issue 4 Pg. 292-297 ISSN: 1557-8674 [Electronic] United States
• PMID: 30785859 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Amikacin
• Meropenem

Topics

• Acinetobacter Infections (drug therapy, pathology)
• Acinetobacter baumannii (isolation & purification)
• Administration, Intravenous
• Adult
• Aged
• Amikacin (administration & dosage)
• Anti-Bacterial Agents (administration & dosage)
• Central Nervous System Infections (drug therapy, pathology)
• Female
• Humans
• Injections, Spinal
• Male
• Meropenem (administration & dosage)
• Middle Aged
• Neurosurgical Procedures (adverse effects)
• Retrospective Studies
• Surgical Wound Infection (drug therapy, pathology)
• Treatment Outcome