Abstract | PURPOSE: This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging. METHODS: We retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005-2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up < 12 months. We defined high and low CONUT according to cut-off of (2). Multivariate Cox-regression analysis was used to predict factors affecting recurrence and survival. Kaplan-Meier curve was used for survival analysis. RESULTS: The median age and follow-up were 56 years and 63 months, respectively. 41 patients had recurrence (3.9%). CONUT was a predictor for recurrence-free, cancer-specific, and overall survival (HR 3.09, P = 0.003 and HR 4.66, P = 0.004 and HR 2.81, P = 0.003, respectively). A higher CONUT was significantly associated with worse 5 years recurrence-free (88.2% vs. 97.1%), cancer-specific (96.2% vs. 98.8%) and overall (90.9% vs. 96.5%) survival (log-rank, P = < 0.001, P = 0.006 and P = < 0.001, respectively). CONCLUSIONS: The preoperative CONUT is an independent prognostic marker for survival after curative surgery for non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.
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Authors | Ahmed Elghiaty, Jongchan Kim, Won Sik Jang, Jee Soo Park, Ji Eun Heo, Koon Ho Rha, Young Deuk Choi, Won Sik Ham |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 145
Issue 4
Pg. 957-965
(Apr 2019)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 30758671
(Publication Type: Journal Article)
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Chemical References |
- Serum Albumin
- Cholesterol
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
(blood, immunology, mortality, surgery)
- Cholesterol
(blood)
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Kidney Neoplasms
(blood, immunology, mortality, surgery)
- Lymphocyte Count
- Male
- Middle Aged
- Nephrectomy
- Nutritional Status
- Predictive Value of Tests
- Preoperative Period
- Retrospective Studies
- Serum Albumin
(metabolism)
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