Cervicitis is a common
sexually transmitted disease. In recent years, the abuse of
antibiotic in the treatment of
cervicitis results in the emergence of
antibiotic-resistant bacteria; alternative strategies are needed to be developed. In this research, we investigated the effects of Feilin
Vaginal Gel (FVG), a Chinese herbal formula, on the treatment of
cervicitis. Two
cervicitis models were optimized using BALB/c mouse; one in vitro model was established in HeLa cells. In Chlamydia trachomatis-induced
cervicitis model, the high level of bacterial loads, the
inflammation in tissue, and the
cytokines in serum could be observed. With the administration of FVG, the bacterial loads in cervical mucus and cervix tissue could be significantly inhibited in dose-dependent manners. The pathological injury of cervix and vagina, as well as the levels of
IL-2,
IL-17, and MCP-1 in serum, could be mitigated by FVG. FVG reduced the number of inclusion induced by C. trachomatis in HeLa cells. In addition, the histological damage in Escherichia coli and Staphylococcus aureus-induced
cervicitis model could be reduced by FVG. These results suggest that FVG is capable of treating
cervicitis through the inhibition of pathogens and the regulation of host immune responses. FVG may contribute as an alternative agent for the treatment of
cervicitis.