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Four C-geranyl flavonoids from the flowers of Paulownia fortunei and their anti-inflammatory activity.

Abstract
Four new C-geranyl flavonoids, paulownione D-G (1-4) were isolated from the 50% acetone-H2O extract of the flowers of Paulownia fortunei. The structures of the compounds were determined by extensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). All of the compounds (1-4) exhibited potent protection effects in H9c2 cardiocytes against the lipopolysaccharide (LPS)-induced inflammation.
AuthorsJing-Ke Zhang, Meng Li, Miao Li, Kun Du, Jinjin Lv, Zhi-Guang Zhang, Xiao-Ke Zheng, Wei-Sheng Feng
JournalNatural product research (Nat Prod Res) Vol. 34 Issue 22 Pg. 3189-3198 (Nov 2020) ISSN: 1478-6427 [Electronic] England
PMID30698037 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavonoids
  • Lipopolysaccharides
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry, pharmacology)
  • Cell Line
  • Drug Evaluation, Preclinical
  • Flavonoids (chemistry, pharmacology)
  • Flowers (chemistry)
  • Inflammation (chemically induced, drug therapy)
  • Lamiales (chemistry)
  • Lipopolysaccharides (toxicity)
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Myocytes, Cardiac (drug effects)
  • Rats

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