Metabolic tumor volume and total lesion glycolysis predict tumor progression and survival after salvage surgery for recurrent oral cavity squamous cell carcinoma.

Abstract

BACKGROUND:

This study evaluated the prognostic role of Fluorine 18-fluorodeoxyglucose positron emission tomography/CT (18 F-FDG PET/CT) parameters quantitatively measured in patients with recurrent oral cavity cancer.

METHODS:

Cox proportional hazards regression analyses were used to assess the associations between quantitative 18 F-FDG PET/CT parameters and other clinicopathological factors and progression-free survival (PFS) and overall survival (OS).

RESULTS:

All of the 18 F-FDG PET parameters (SUVmax , SUVmean , SUVpeak , metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) were significantly associated with poor PFS and OS outcomes after salvage treatment (P < .01). In multivariate analyses, Karnofsky performance score, recurrence site, MTV, and TLG were independent variables predictive of both PFS and OS (P < .05). High MTV (>8.8 mL) or TLG (>29.4 g) values at recurrent lesions were associated with >5-fold increased risk for tumor progression and mortality after salvage surgery.

CONCLUSIONS:

The PET parameters of MTV and TLG measured at recurrent lesions may predict tumor progression and survival after salvage treatment.

CONDENSED ABSTRACT:

This study examined the role of 18 F-FDG PET/CT at recurrent staging for predicting tumor progression and survival in 71 consecutive patients with recurrent oral cavity squamous cell carcinomas. Of 18 F-FDG parameters, metabolic tumor volume and total lesion glycolysis were independent factors predictive of tumor progression and survival after salvage treatment.

• Authors: Woo Ri Choi, Jungsu S Oh, Jong-Lyel Roh, Jae Seung Kim, Inhye Oh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
• Journal: Head & neck (Head Neck) Vol. 41 Issue 6 Pg. 1846-1853 (06 2019) ISSN: 1097-0347 [Electronic] United States
• PMID: 30675738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Fluorodeoxyglucose F18

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, pathology, therapy)
• Cohort Studies
• Female
• Fluorodeoxyglucose F18
• Glycolysis
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (mortality, pathology, therapy)
• Positron Emission Tomography Computed Tomography
• Salvage Therapy
• Survival Rate
• Treatment Outcome
• Tumor Burden