Abstract | PROBLEM: METHOD OF STUDY: We included 51 women with normotensive pregnancies and 54 women with pregnancies complicated by pre-eclampsia. Blood samples were obtained at gestational weeks 16, 33, 37, and after delivery for the normotensive pregnant women and before and after delivery for women with pre-eclampsia. Mannose-binding lectin (MBL), H- and M-ficolin, collectin liver-1 (CL-L1), MBL-associated serine protease (MASP)-1, MASP-2 and MASP-3 and MBL-associated proteins of 19 (MAp19) and 44 (MAp44) kDa were analysed. Clinical information was obtained from medical records. The placentae were examined by two experienced perinatal pathologists. RESULTS:
Lectin pathway protein concentrations generally increased during normal pregnancy and decreased after delivery in both normotensive pregnant women and women with pre-eclampsia. Exceptions were MASP-3 which increased after delivery in both groups (P < 0.0001) and H-ficolin which increased after delivery in pre-eclampsia (P < 0.0001). H-ficolin (P < 0.0001), M-ficolin (P = 0.005) and MASP-3 (P = 0.03) concentrations were lower in women with pre-eclampsia than in normotensive pregnant women. Low MASP-3 concentrations were associated with placental infarction (P = 0.03) and IUGR (P = 0.04). Low H-ficolin concentrations were associated with IUGR (P < 0.01). CONCLUSION:
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Authors | Julie Brogaard Larsen, Anita Sylvest Andersen, Christine Lodberg Hvas, Steffen Thiel, Michael Rud Lassen, Anne-Mette Hvas, Anette Tarp Hansen |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 81
Issue 4
Pg. e13092
(04 2019)
ISSN: 1600-0897 [Electronic] Denmark |
PMID | 30672631
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- FCN3 protein, human
- Lectins
- Mannose-Binding Lectin
- MASP1 protein, human
- Mannose-Binding Protein-Associated Serine Proteases
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Topics |
- Adult
- Biomarkers
(blood)
- Complement Activation
- Complement Pathway, Mannose-Binding Lectin
- Female
- Fetal Growth Retardation
(immunology)
- Humans
- Infarction
(immunology)
- Lectins
(blood)
- Mannose-Binding Lectin
(blood)
- Mannose-Binding Protein-Associated Serine Proteases
(metabolism)
- Placenta
(physiology)
- Pre-Eclampsia
(immunology)
- Pregnancy
- Ficolins
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