Abstract | BACKGROUND: Oxidative stress is one of the major mechanism involved in pathogenesis of myocardial infarction. Use of natural products as therapeutic approach for ischemic myocardial injury is gaining attention worldwide. PURPOSE: METHODS: After 3-days pretreatment with NRF (100 mg/kg and 200 mg/kg, p.o.) myocardial injury was induced by subcutaneous administration of isoproterenol (85 mg/kg) for 2 days. Hemodynamic parameters, biochemical parameters, histological and ultrastructural changes were observed. RESULTS: CONCLUSION:
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Authors | Shagufta Shaikh, Lokesh Kumar Bhatt, Kalyani Barve |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 55
Pg. 222-228
(Mar 01 2019)
ISSN: 1618-095X [Electronic] Germany |
PMID | 30668432
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier GmbH. All rights reserved. |
Chemical References |
- Adrenergic beta-Agonists
- Disaccharides
- Flavanones
- narirutin
- Isoproterenol
|
Topics |
- Adrenergic beta-Agonists
(toxicity)
- Animals
- Cardiotoxicity
(etiology)
- Citrus paradisi
(chemistry, toxicity)
- Disaccharides
(toxicity)
- Flavanones
(toxicity)
- Heart
(physiopathology)
- Isoproterenol
(toxicity)
- Male
- Myocardial Infarction
(chemically induced)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Wistar
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