Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms.

Abstract

Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient's quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10⁻15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures.

• Authors: Minghan Chi, Manlin Qi, Lan A, Ping Wang, Michael D Weir, Mary Anne Melo, Xiaolin Sun, Biao Dong, Chunyan Li, Junling Wu, Lin Wang, Hockin H K Xu
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 2 (Jan 11 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 30641958 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Dental Materials
• Polymers

Topics

• Anti-Bacterial Agents (chemical synthesis, chemistry, pharmacology)
• Bacteria (drug effects, growth & development)
• Biofilms (drug effects)
• Dental Materials (chemical synthesis, chemistry)
• Drug Delivery Systems
• Humans
• Periodontitis (microbiology, therapy)
• Photochemotherapy
• Polymers (chemical synthesis, chemistry, pharmacology)
• Quality of Life