Abstract | BACKGROUND AND AIM: METHODS: We recruited 164 infants (age < 6 months) hospitalized for bronchiolitis in this study and determined TLR5 rs5744174 (C > T) single nucleotide polymorphism, virus etiology and severity markers of bronchiolitis, and presence of post- bronchiolitis asthma until age 11 to 13 years. RESULTS: RSV was detected in 113 (68.9%), rhinovirus in 19 (11.6%), and some other virus in 20 (12.2%) cases. Non-RSV etiology was more common among infants with the variant CT or TT genotype in the TLR5 rs5744174 gene than in those with the CC genotype (89.7% vs 71.7%, P = 0.03). TLR5 rs5744174 polymorphism was not associated with the need of supplementary oxygen or feeding support, with the length of hospital stay, or with post- bronchiolitis asthma at any age. CONCLUSION: The TLR5 rs5744174 variant genotype may increase the susceptibility to bronchiolitis not caused by RSV.
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Authors | Sari Törmänen, Johanna Teräsjärvi, Eero Lauhkonen, Merja Helminen, Petri Koponen, Matti Korppi, Kirsi Nuolivirta, Qiushui He |
Journal | Health science reports
(Health Sci Rep)
Vol. 1
Issue 6
Pg. e38
(Jun 2018)
ISSN: 2398-8835 [Electronic] United States |
PMID | 30623075
(Publication Type: Journal Article)
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