Abstract | BACKGROUND: There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neurotoxicity. Furthermore, chemotherapy resistance occurs more and more frequently. Therefore, effective treatment strategies are needed. Histone deacetylase 6 inhibition is considered as a potential therapeutic strategy for acute leukemia, since it is observed that HDAC6 is overexpressed in acute leukemia and regulates tumor survival. Combination therapy for cancer is used to minimize adverse drug effects, reduce drug dosage, enhance efficacy, and prevent drug resistance. In order to improve efficacy of chemotherapy agents of acute leukemia, this study will investigate the effects of combination MPT0G211, a novel histone deacetylase 6 inhibitor, with doxorubicin or vincristine on human acute leukemia cells. RESULTS: CONCLUSIONS: Collectively, our data highlighted that MPT0G211 in combination with chemotherapy drugs has significant anticancer activity, suggesting a novel strategy for the treatment of acute leukemia.
|
Authors | Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang |
Journal | Clinical epigenetics
(Clin Epigenetics)
Vol. 10
Issue 1
Pg. 162
(12 29 2018)
ISSN: 1868-7083 [Electronic] Germany |
PMID | 30594243
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Benzamides
- Histone Deacetylase Inhibitors
- Vincristine
- Doxorubicin
- HDAC6 protein, human
- Histone Deacetylase 6
|
Topics |
- Animals
- Benzamides
(administration & dosage, pharmacology)
- Cell Cycle
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Doxorubicin
(administration & dosage, pharmacology)
- Drug Synergism
- HL-60 Cells
- Histone Deacetylase 6
(antagonists & inhibitors)
- Histone Deacetylase Inhibitors
(administration & dosage, pharmacology)
- Humans
- Leukemia, Myeloid, Acute
(drug therapy, metabolism)
- Mice
- Vincristine
(administration & dosage, pharmacology)
- Xenograft Model Antitumor Assays
|