Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins.

Abstract

Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other. This study will focus on the origins and actions of all three markers during pregnancy and outside pregnancy and will describe a scenario where all three markers act synergistically to rescue the mother from the deleterious effects of the debris that is released from the placenta during preeclampsia. This more holistic approach may open new avenues to think about maternal-fetal interactions and putative therapies.

• Authors: Berthold Huppertz
• Journal: Biochimica et biophysica acta. Molecular basis of disease (Biochim Biophys Acta Mol Basis Dis) Vol. 1866 Issue 2 Pg. 165349 (02 01 2020) ISSN: 1879-260X [Electronic] Netherlands
• PMID: 30553017 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Angiogenesis Inducing Agents
• Biomarkers
• Galectins
• LGALS13 protein, human
• PGF protein, human
• Pregnancy Proteins
• Placenta Growth Factor
• FLT1 protein, human
• Vascular Endothelial Growth Factor Receptor-1

Topics

• Angiogenesis Inducing Agents (metabolism)
• Biomarkers (metabolism)
• Female
• Galectins
• Humans
• Placenta (metabolism)
• Placenta Growth Factor (metabolism)
• Pre-Eclampsia (diagnosis, etiology, metabolism)
• Pregnancy
• Pregnancy Proteins (metabolism)
• Sepsis
• Vascular Endothelial Growth Factor Receptor-1 (metabolism)
• Vasodilation