Abstract | BACKGROUND: Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations in a nested case-control study within the California Teachers Study. METHODS: RESULTS: For all cases of invasive breast cancer, none of the adjusted ORs were statistically significant but marginally significant ORs < 1.0 were observed for PFUnDA and PFHxS (p-trend = 0.08). Adjusted ORs < 1.0 for PFUnDA and PFHxS were statistically significant (p ≤ 0.05) among the 107 cases with hormone-negative tumors but not the 743 with hormone-positive tumors. CONCLUSION: Overall, these findings do not provide evidence that serum PFAS levels measured after diagnosis are related to breast cancer risk. The few inverse associations found may be due to chance or may be artifacts of study design. Future studies should incorporate information about genetic susceptibility, endogenous estrogen levels, and measurements of PFASs prior to diagnosis and treatment.
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Authors | Susan Hurley, Debbie Goldberg, Miaomiao Wang, June-Soo Park, Myrto Petreas, Leslie Bernstein, Hoda Anton-Culver, David O Nelson, Peggy Reynolds |
Journal | Environmental health : a global access science source
(Environ Health)
Vol. 17
Issue 1
Pg. 83
(11 27 2018)
ISSN: 1476-069X [Electronic] England |
PMID | 30482205
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alkanesulfonic Acids
- Environmental Pollutants
- Fatty Acids
- Fluorocarbons
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alkanesulfonic Acids
(blood)
- Breast Neoplasms
(blood, epidemiology)
- California
(epidemiology)
- Case-Control Studies
- Environmental Monitoring
- Environmental Pollutants
(blood)
- Fatty Acids
(blood)
- Female
- Fluorocarbons
(blood)
- Humans
- Middle Aged
- Odds Ratio
- Risk
- Young Adult
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