Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging.
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| Abstract |
Facile approach was established to fabricate the hybrid cluster bombs of PEGylated chitosan encapsulated doxorubicin (DOX)-loaded superparamagnetic nanoparticles as tumor-specific theranostics for targeted DOX delivery and magnetic resonance (MR) imaging, by simply co-precipitation of poly(ethylene glycol) modified chitosan (CS-PEG), oleylamine modified Fe3O4 (OA-Fe3O4) nanoparticles and DOX. In presence of OA-Fe3O4, the particle size of the DOX/OA-Fe3O4@CS-PEG cluster bombs decreased to around 80 nm from 300 nm of the DOX/CS-PEG nanoparticles, with high drug-loading capacity (DLC) of 24.3% and saturation magnetization (Ms) of 4.11 emu/g, respectively. The in vitro evaluation results indicated that the blank OA-Fe3O4@CS-PEG clusters showed excellent cytocompatibility, while the DOX/OA-Fe3O4@CS-PEG clusters could be uptaken into HepG2 cells to deliver DOX into the cell nuclei with enhanced anti-cancer efficacy in comparison with free DOX. In the tumor intracellular micro-environment, the stimuli-responsive hybrid cluster bombs disassembled and re-self-assembled into the OA-Fe3O4 nanoparticle clusters with higher Ms for MR imaging-guided diagnosis, owing to the tumor-specific DOX release and dissolution of CS-PEG.
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| Authors | Pengwei Xie, Pengcheng Du, Jiagen Li, Peng Liu |
| Journal | Carbohydrate polymers (Carbohydr Polym) Vol. 205 Pg. 377-384 (Feb 01 2019) ISSN: 1879-1344 [Electronic] England |
| PMID | 30446118 (Publication Type: Journal Article) |
| Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
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