MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma.

Abstract

Cell-based drug delivery systems have shown promising capability for tumor-targeted therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells. However, imaging tracking of their migration and bio-effects is urgently needed for clinical application, especially for glioma. Here, we report the inflammation-activatable engineered neutrophils by internalizing doxorubicin-loaded magnetic mesoporous silica nanoparticles (ND-MMSNs) which can provide the potential for magnetic resonance (MR) imaging tracking of the drug-loaded cells to actively target inflamed brain tumor after surgical resection of primary tumor. The phagocytized D-MMSNs possess high drug loading efficiency and do not affect the host neutrophils' viability, thus remarkably improving intratumoral drug concentration and delaying relapse of surgically treated glioma. Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers.

• Authors: Meiying Wu, Haixian Zhang, Changjun Tie, Chunhong Yan, Zhiting Deng, Qian Wan, Xin Liu, Fei Yan, Hairong Zheng
• Journal: Nature communications (Nat Commun) Vol. 9 Issue 1 Pg. 4777 (11 14 2018) ISSN: 2041-1723 [Electronic] England
• PMID: 30429468 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Drug Carriers
• Silicon Dioxide
• Doxorubicin
• Ferrosoferric Oxide

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage)
• Brain Neoplasms (drug therapy, surgery)
• Cell Movement
• Cell Tracking
• Chemotherapy, Adjuvant
• Doxorubicin (administration & dosage)
• Drug Carriers
• Drug Delivery Systems
• Extracellular Traps
• Ferrosoferric Oxide
• Glioma (drug therapy, surgery)
• Magnetic Resonance Imaging
• Magnets
• Mice
• Microscopy, Electron, Transmission
• Nanoparticles
• Neutrophils
• Silicon Dioxide