Abstract | BACKGROUND: Given the seriousness of chemotherapy-induced ovarian injury in female cancer patients, the preservation of fertility, including through the use of cryopreservation technology and pharmaceuticals, requires investigation. Previous studies have shown that damage to the ovaries is related to oxidative stress caused by anticancer drugs. Therefore, superoxide dismutase (SOD) may represent a key factor in the pharmacological protection of the ovaries. The aim of our study was to identify the effects of mangafodipir, a manganese chelate and SOD-mimetic, on suppression of apoptosis in granulosa cells and primordial follicle activation induced by anticancer drugs. METHODS: RESULTS: CONCLUSIONS: Oxidative stress might be one of the mechanisms of cisplatin- and paclitaxel-induced the loss of primordial follicles. Mangafodipir can reduce cisplatin- and paclitaxel-induced apoptosis in granulosa cells and primordial follicle activation partially via its SOD activity. At the same time, mangafodipir might have other potential mechanisms to inhibit the activation of primordial follicles. Further, mangafodipir attenuated the ovarian damage caused by cisplatin and paclitaxel without affecting their antitumor activities. Mangafodipir, therefore, though its efficacy might be limited, may be a new option for the preservation of fertility during anticancer treatment.
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Authors | Ying Qin, Akira Iwase, Tomohiko Murase, Bayasula, Chiharu Ishida, Nao Kato, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa |
Journal | Reproductive biology and endocrinology : RB&E
(Reprod Biol Endocrinol)
Vol. 16
Issue 1
Pg. 106
(Oct 27 2018)
ISSN: 1477-7827 [Electronic] England |
PMID | 30368246
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Contrast Media
- Protective Agents
- Pyridoxal Phosphate
- Edetic Acid
- Caspase 3
- N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
- Paclitaxel
- Cisplatin
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Caspase 3
(metabolism)
- Cell Line
- Cell Line, Tumor
- Cisplatin
(pharmacology)
- Contrast Media
(pharmacology)
- Edetic Acid
(analogs & derivatives, pharmacology)
- Female
- Granulosa Cells
(cytology, drug effects, metabolism)
- Humans
- Mice, Inbred BALB C
- Mice, Inbred ICR
- Mice, Nude
- Ovarian Follicle
(drug effects, metabolism)
- Ovary
(drug effects, metabolism)
- Oxidative Stress
(drug effects)
- Paclitaxel
(pharmacology)
- Protective Agents
(pharmacology)
- Pyridoxal Phosphate
(analogs & derivatives, pharmacology)
- Xenograft Model Antitumor Assays
(methods)
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