Abstract | BACKGROUND: METHOD: The study included 10 patients with PD and striatal foot deformity who visited a neurological clinic. The mean ± standard deviation age and PD-duration was 62.8 ± 8.8 years and 4.9 ± 3.6 years, respectively. Clinical assessment was made before and 4 and 16 weeks after injection and included 5 clinical gait and balance tests. The intensity of distress due to deformities was investigated with a visual analogue scale. Parkinsonian motor status was assessed with the Unified Parkinson's Disease Rating Scale part III (motor part). Based on ordinary clinical examination, electromyography-guided BoNT A injection was given in affected muscles. Clinically effective doses of BoNT A were used. RESULTS: Improvements were observed regarding functional, dynamic, and standing balance as well as intensity of distress at 4 weeks but not at 16 weeks compared with baseline. CONCLUSIONS:
BoNT A injection treatment improved gait and balance in patients with PD and striatal foot deformities. Multicenter trials are needed; and, to achieve increased power, a randomized, double-blind controlled design is needed and should focus on the ability of tests to capture subtle changes in gait and balance.
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Authors | Beata Lindholm, Anders Beckman, Wojciech Duzynski, Eva Ekvall Hansson |
Journal | Movement disorders clinical practice
(Mov Disord Clin Pract)
2017 May-Jun
Vol. 4
Issue 3
Pg. 309-315
ISSN: 2330-1619 [Electronic] United States |
PMID | 30363465
(Publication Type: Journal Article)
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