[CLINICAL EFFICIENCY OF CYCLOFERON IN CHILDREN AND ADULTS WITH HIV AND/ OR HERPES INFECTION: SYSTEMATIC REVIEW AND META-ANALYSIS].

Abstract

Aim was to estimate and compare clinical efficiency of cycloferon use against basic therapy in treatment of HIV and/ or herpes infection. There were comparisons of treatment results with patient (n=1274) groups' heterogeneity taken into account. 9 randomized clinical trials with cycloferon efficacy data were mobilized, in all studies there were protocols of injections, tablets or liniments cycloferon administration. Homogeneous and symmetric groups combination during meta-analysis increased statistic power of comparisons and led to integrative efficiency assessment, proved its' stability in statistic models. Cycloferon use in children and adults with HIV and/ or herpes infection was more the 3 times more effective to provide stable remission and exacerbation frequency diminish against basic therapy.

• Authors: N Mazina, P Mazin, A Kovalenko
• Journal: Georgian medical news (Georgian Med News) Issue 282 Pg. 121-129 (Sep 2018) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 30358555 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Acridines
• Antiviral Agents
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (therapeutic use)
• Adult
• Antiviral Agents (therapeutic use)
• Child
• Coinfection
• HIV Infections (drug therapy)
• Herpesviridae Infections (drug therapy)
• Humans
• Treatment Outcome