Abstract |
The link between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is widely recognized. Considering the strong association between raised antithyroidperoxidase antibody (TPOAb) and CLT, we postulated that the preoperative TPOAb can predict the prognosis of PTC, particularly for recurrence. A total of 2,070 patients who underwent total thyroidectomy for classical type PTC with tumor size ≥1 cm and with available data on preoperative TPOAb and TgAb were enrolled to compare disease-free survival (DFS) according to the presence of preoperative TPOAb, TgAb, and coexistent CLT. Patients with positive preoperative TPOAb had a significantly better DFS compared to patients without positive preoperative TPOAb (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.30-0.94, p = 0.028) while no difference in DFS was found according to preoperative TgAb status. Positive preoperative TPOAb was an independent prognostic factor for structural persistent/recurrent disease after adjustment for major preoperative risk factors such as age, sex, and tumor size (HR 0.52, 95% CI 0.28-0.99, p = 0.048). Although the coexistence of CLT lowered the risk for structural persistence/recurrence in univariate analysis (HR 0.52, 95% CI 0.31-0.86, p = 0.012), it was not an independent favorable prognostic factor by multivariate analysis (HR 0.65, 95% CI 0.38-1.10, p = 0.106). However, when coexistent CLT was combined with positive preoperative TPOAb, it indicated an independent protective role in structural persistent/recurrent disease (HR 0.39, 95% CI 0.16-0.98, p = 0.045). Our study clearly showed that presence of preoperative TPOAb can be a novel prognostic factor in predicting structural persistence/recurrence of PTC.
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Authors | Eyun Song, Hye-Seon Oh, Min Ji Jeon, Ki Wook Chung, Suck Joon Hong, Jin Sook Ryu, Jung Hwan Baek, Jeong Hyun Lee, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim |
Journal | International journal of cancer
(Int J Cancer)
Vol. 144
Issue 6
Pg. 1414-1420
(03 15 2019)
ISSN: 1097-0215 [Electronic] United States |
PMID | 30357831
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 UICC. |
Chemical References |
- Autoantibodies
- Autoantigens
- Biomarkers, Tumor
- Iron-Binding Proteins
- TPO protein, human
- Iodide Peroxidase
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Topics |
- Adult
- Autoantibodies
(blood, immunology)
- Autoantigens
(immunology)
- Biomarkers, Tumor
(blood, immunology)
- Disease-Free Survival
- Female
- Hashimoto Disease
(blood, immunology, mortality, pathology)
- Humans
- Iodide Peroxidase
(immunology)
- Iron-Binding Proteins
(immunology)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis)
- Preoperative Period
- Prognosis
- Retrospective Studies
- Survival Analysis
- Thyroid Cancer, Papillary
(blood, immunology, mortality, surgery)
- Thyroid Neoplasms
(blood, immunology, mortality, surgery)
- Thyroidectomy
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