Clinical Efficacy of Serum-Derived Bovine Immunoglobulin in Patients With Refractory Inflammatory Bowel Disease.

Abstract

BACKGROUND:

Inflammatory bowel disease (IBD) can have autoimmunity and/or intestinal barrier dysfunction as part of pathophysiology and may be refractory to all available treatment options. Serum-derived bovine immunoglobulin (SBI) binds microbial components with postulated downstream effects of normalized gut immune and barrier function, which may be useful for managing IBD. The purpose of our study was to evaluate the effectiveness of SBI in the management of refractory IBD, particularly symptoms of chronic diarrhea and loose stools.

METHODS:

We retrospectively analyzed charts for patients diagnosed with IBD (n = 40) who were refractory to standard treatment. Patients received oral SBI 5 g daily for a period of at least 6 weeks. Twelve patients with IBD fulfilled study inclusion criteria. Each patient graded the severity and frequency of gastrointestinal symptoms before starting SBI and at 6 weeks of treatment using a standardized patient assessment form. Means and standard deviations for all symptom scores at baseline and week 6 of treatment were analyzed.

RESULTS:

Mean symptom scores decreased significantly for nausea (P = 0.02 for severity and P = 0.03 for mean symptom score) and diarrhea (P = 0.0006, P = 0.0001 and P = 0.0001 for severity, frequency and mean symptom score, respectively).

CONCLUSIONS:

Therapy with SBI alleviated some refractory gastrointestinal symptoms in patients with IBD, including nausea and diarrhea. Increased duration, dosage and/or frequency of SBI might provide additional symptom improvement and could be tested through controlled clinical trials with larger sample sizes and longer follow-up.

• Authors: Hammad Liaquat, Munish Ashat, Abigail Stocker, Lindsay McElmurray, Karen Beatty, Thomas L Abell, Gerald Dryden
• Journal: The American journal of the medical sciences (Am J Med Sci) Vol. 356 Issue 6 Pg. 531-536 (12 2018) ISSN: 1538-2990 [Electronic] United States
• PMID: 30342719 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Immunoglobulins
• Immunologic Factors

Topics

• Adult
• Aged
• Animals
• Cattle
• Diarrhea (drug therapy, microbiology)
• Female
• Humans
• Immunoglobulins (therapeutic use)
• Immunologic Factors (therapeutic use)
• Inflammatory Bowel Diseases (drug therapy, microbiology)
• Male
• Middle Aged
• Retrospective Studies
• Treatment Outcome
• Young Adult