Abstract | AIM: This cross-sectional investigation evaluated whether recurrent botulinum neurotoxin A ( BoNT-A) interventions to the medial gastrocnemius have an influence on muscle morphology, beyond Gross Motor Function Classification System (GMFCS) level. METHOD: A cohort of typically developing children (n=67; 43 males, 24 females; median age 9y 11mo [range 7y 10mo-11y 6mo]), a cohort of children with spastic cerebral palsy (CP) naive to BoNT-A interventions (No- BoNT-A; n=19; 10 males, nine females; median age 9y 3mo [range 8y 5mo-10y 10mo]) and a cohort of children with spastic CP with a minimum of three recurrent BoNT-A interventions to the medial gastrocnemius ( BoNT-A; n=19; 13 males, six females; median age 9y 8mo [range 7y 3mo-10y 7mo]) were recruited. Three-dimensional freehand ultrasound was used to estimate medial gastrocnemius volume normalized to body mass and echo-intensity. RESULTS: Normalized medial gastrocnemius volume and echo-intensity significantly differed between the two spastic CP cohorts (p≤0.05), with the BoNT-A cohort having larger alterations. Associations between normalized medial gastrocnemius volume and echo-intensity were highest in the No- BoNT-A cohort, followed by the BoNT-A cohort. Multiple regression analyses revealed that both GMFCS level and BoNT-A intervention history were significantly associated with smaller normalized medial gastrocnemius volume and higher echo-intensity. INTERPRETATION: Recurrent BoNT-A interventions may induce alterations to medial gastrocnemius volume and echo-intensity beyond the natural history of the spastic CP pathology. WHAT THIS PAPER ADDS: In spastic cerebral palsy, medial gastrocnemius volumes are smaller and echo-intensities higher compared with typical development. Alterations after botulinum neurotoxin A intervention ( BoNT-A) are larger than in no BoNT-A intervention. Gross Motor Function Classification System level and BoNT-A history significantly associate with medial gastrocnemius and echo-intensity alterations.
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Authors | Simon-Henri Schless, Francesco Cenni, Lynn Bar-On, Britta Hanssen, Barbara Kalkman, Thomas O'brien, Erwin Aertbeliën, Anja Van Campenhout, Guy Molenaers, Kaat Desloovere |
Journal | Developmental medicine and child neurology
(Dev Med Child Neurol)
Vol. 61
Issue 7
Pg. 783-790
(07 2019)
ISSN: 1469-8749 [Electronic] England |
PMID | 30320442
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 Mac Keith Press. |
Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Botulinum Toxins, Type A
(administration & dosage)
- Cerebral Palsy
(complications, drug therapy, pathology, physiopathology)
- Child
- Cohort Studies
- Female
- Humans
- Imaging, Three-Dimensional
- Injections, Intramuscular
- Leg
- Male
- Muscle Spasticity
(drug therapy, etiology, pathology, physiopathology)
- Muscle, Skeletal
(diagnostic imaging, drug effects, pathology)
- Neuromuscular Agents
(administration & dosage)
- Organ Size
- Treatment Outcome
- Ultrasonography
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