Abstract | INTRODUCTION: MATERIALS AND METHODS: RESULTS: The network meta-analysis included 1340 patients from nine studies. There were no significant differences in the risks of mortality and bleeding complications among all direct comparisons and the network meta-analysis. Using a placebo was associated with a significantly lower rate of DIC resolution, compared to antithrombin in the direct comparison (odds ratio [OR]: 0.20, 95% credible interval [95% CrI]: 0.046-0.81) and in the network meta-analysis (OR: 0.20, 95% CrI: 0.043-0.84). CONCLUSIONS: Our study revealed no significant differences in the risks for mortality and bleeding complications when a placebo and all four anticoagulants were compared in septic DIC patients. The results also indicated that antithrombin was associated with a five-fold higher likelihood of DIC resolution, compared to placebo.
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Authors | Tomoaki Yatabe, Shigeaki Inoue, So Sakamoto, Yuka Sumi, Osamu Nishida, Kei Hayashida, Yoshitaka Hara, Tatsuma Fukuda, Asako Matsushima, Akihisa Matsuda, Hideto Yasuda, Kazuto Yamashita, Moritoki Egi |
Journal | Thrombosis research
(Thromb Res)
Vol. 171
Pg. 136-142
(11 2018)
ISSN: 1879-2472 [Electronic] United States |
PMID | 30312798
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticoagulants
- Antithrombins
- Protease Inhibitors
- Thrombomodulin
- Heparin
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Topics |
- Adult
- Aged
- Anticoagulants
(adverse effects, therapeutic use)
- Antithrombins
(adverse effects, therapeutic use)
- Critical Illness
(epidemiology, mortality)
- Disseminated Intravascular Coagulation
(drug therapy, etiology, mortality)
- Female
- Hemorrhage
(chemically induced, mortality)
- Heparin
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Protease Inhibitors
(adverse effects, therapeutic use)
- Risk Factors
- Sepsis
(complications, mortality)
- Thrombomodulin
(therapeutic use)
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