The clinical efficacy of using autologous platelet-rich plasma in total hip arthroplasty: A retrospective comparative study.

Abstract

This study evaluated whether intra-articular platelet-rich plasma (PRP) might prevent postoperative bleeding in total hip arthroplasty (THA).In this study, 260 hips that underwent THA were evaluated randomly by paramedical staffs, 130 of which involved the intraoperative use of PRP, and 130 of which served as control group. Postoperative blood loss (drain bag volume), estimated blood loss, and change in hemoglobin (Hb) at day 1, 2, 4, and 7 were analyzed, respectively.PRP-treated group had a significant decrease in mean postoperative blood loss (92.6 ± 168.2 mL) compared to control group (682.3 ± 185.5 mL, P < .01). The mean postoperative estimated blood loss (526.1 ± 236.1 mL) in the PRP-treated group was significantly less than that in the control group (629.2.2 ± 142.3 mL, P < .01). There was a statistically significant difference in Hb value (mg/dL) at day 1, 2, 4, and 7 (-1.35 vs -1.98, -1.59 vs -2.52, -1.96 vs -2.82, and -1.76 vs -2.47, P < .05).We found a significant reduction in postoperative blood loss (drain bag volume), estimated blood loss, and change in Hb after the use of autologous platelet gel in patients of THA, and PRP appears to be effective in reducing postoperative bleeding in THA.

• Authors: Xi Wang, Jianbin Ma, Zhiyuan Wang, Lin Xiao
• Journal: Medicine (Medicine (Baltimore)) Vol. 97 Issue 40 Pg. e12451 (Oct 2018) ISSN: 1536-5964 [Electronic] United States
• PMID: 30290603 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hemoglobins

Topics

• Aged
• Arthroplasty, Replacement, Hip (adverse effects, methods)
• Blood Transfusion, Autologous (methods)
• Female
• Hemoglobins (analysis)
• Humans
• Intraoperative Care (methods)
• Male
• Middle Aged
• Platelet-Rich Plasma
• Postoperative Hemorrhage (etiology, prevention & control)
• Postoperative Period
• Retrospective Studies
• Treatment Outcome