Abstract | INTRODUCTION: OBJECTIVES: The possible preventive effect of N-acetylcysteine in cisplatin ototoxicity was studied with auditory brain stem responses, otoacoustic emissions, and histopathological investigation of the cochlea in a scanning electron microscopy. METHODS: This study was conducted on 21 Wistar Albino rats in four groups. 1mL/kg/day three times in total intraperitoneal (i.p.) Saline (n=5), 500mg/kg/day i.p. three times in total N-acetylcysteine (n=5), i.p. 15mg/kg cisplatin alone (single dose) (n=5) and i.p. 15mg/kg cisplatin plus 500mg/kg/day N-acetylcysteine (n=6) were administered. The rats were anesthetized to study the hearing tests before and after the experiment. The rats were sacrificed to investigate the cochleas by scanning electron microscopy. RESULTS: Auditory brain stem responses and otoacoustic emissions values were attenuated in the cisplatin group. The group that received N-acetylcysteine in addition to cisplatin had better auditory brain stem responses thresholds and otoacoustic emissions. The samples obtained from the cisplatin group showed surface irregularities, degeneration areas, and total or partial severe stereocilia losses. The changes were milder in the cisplatin+N- acetylcysteine group. CONCLUSION:
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Authors | Mehmet Akif Somdaş, İnayet Güntürk, Esra Balcıoğlu, Deniz Avcı, Cevat Yazıcı, Saim Özdamar |
Journal | Brazilian journal of otorhinolaryngology
(Braz J Otorhinolaryngol)
2020 Jan - Feb
Vol. 86
Issue 1
Pg. 30-37
ISSN: 1808-8686 [Electronic] Brazil |
PMID | 30268784
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Antioxidants
- Protective Agents
- Cisplatin
- Acetylcysteine
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Topics |
- Acetylcysteine
(administration & dosage, pharmacology)
- Animals
- Antineoplastic Agents
(adverse effects)
- Antioxidants
(administration & dosage, pharmacology)
- Apoptosis
- Cisplatin
(adverse effects)
- Cochlea
(drug effects, pathology)
- Disease Models, Animal
- Evoked Potentials, Auditory, Brain Stem
- Hair Cells, Auditory, Outer
(drug effects, pathology)
- Hearing Tests
- Male
- Microscopy, Electron, Scanning
- Ototoxicity
(etiology, prevention & control)
- Protective Agents
(administration & dosage, pharmacology)
- Rats, Wistar
- Signal-To-Noise Ratio
- Stereocilia
(drug effects, pathology)
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