ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer.

Abstract

The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.

• Authors: Prachi Mishra, Wei Tang, Stefan Ambs
• Journal: Molecular & cellular oncology (Mol Cell Oncol) Vol. 5 Issue 3 Pg. e1432260 ( 2018) ISSN: 2372-3556 [Print] United States
• PMID: 30250890 (Publication Type: Journal Article)