[The favorable effects of KIR3DS1 and Bw4(80Ile) on viral set point and CD4 count decline in HIV-1 patients with acutely infected with HIV-1 infection].

Abstract

Objective: To investigate whether killer cell immunoglobulin-like receptor 3DS1(KIR3DS1)and Bw4(80Ile) could play a protective role during HIV-1 infection. Methods: KIR3DL1/3DS1 and Bw4, Bw6 were genotyped by SSP-PCR and Bw4 allotypes (Bw4(80Ile) and Bw4(80Thr))were classified via sequencing among 109 individuals acutely infected with HIV-1 in Beijing You'an Hospital between 2006 and 2012. Results: (1)Of the 109 patients, 65, 7, and 37 subjects respectively harbored KIR3DL1/KIR3DL1, KIR3DS1/KIR3DS1, and KIR3DL1/KIR3DS1 genotypes. Their viral set points were determined as 4.35±0.79, 4.24±0.49 and 3.99±0.85 respectively. The viral set point of patients carrying KIR3DL1/KIR3DS1 was significantly lower than the KIR3DL1/KIR3DL1 genotype patients (P=0.032). (2)26, 41, 42 subjects harbored Bw4(80Ile,) Bw4(80Thr,) Bw6/6, respectively. Viral set points of these subjects were respectively 3.89±0.49, 4.20±1.03 and 4.44±0.59.One-way ANOVA indicated that Bw4(80Ile)influenced the levels of viral set point(P=0.027). Moreover, the level of viral set point of the Bw4(80Ile) genotype was significantly lower than the Bw6/6 genotype (P=0.020). These outcomes indicated Bw4(80Ile) was associated with lower levels of viral set point.(3)Viral set point of patients harboring KIR3DS1 and Bw4(80Ile)was 3.26±0.81 and significantly lower than individuals possessing other genotypes (all P<0.05). KIR3DS1 and Bw4(80Ile) conferred an advantage over other genotypes, especially over KIR3DS1 and Bw6/6 (P=0.006), KIR3DL1 and Bw6/6 (P=0.015) and even KIR3DL1 and Bw4(80Ile) (P=0.019 6) in delaying CD4 count decline within 3 years after HIV-1 infection. Conclusions: KIR3DS1 and Bw4(80Ile) are synergistically related to lower viral set point and slowing down the CD4 count decline as Bw4(80Ile) in the presence of KIR3DS1.

• Authors: R Wang, Y Liu, X F Lu, Z Y Liu, Z Li, X Zhang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 98 Issue 35 Pg. 2819-2823 (Sep 18 2018) ISSN: 0376-2491 [Print] China
• PMID: 30248785 (Publication Type: Journal Article)

Chemical References

• HLA-B Antigens
• Receptors, KIR3DS1

Topics

• CD4 Lymphocyte Count
• Genotype
• HIV Infections
• HIV-1
• HLA-B Antigens
• Humans
• Killer Cells, Natural
• Receptors, KIR3DS1