The clinical importance of a cytokine network in the acute phase of sepsis.

Abstract

Sepsis remains a major cause of death. Cytokines interact closely with each other and play a crucial role in the progression of sepsis. We focussed on the associations of a cytokine network with prognosis and disease severities in sepsis. This retrospective study included 31 patients with sepsis and 13 healthy controls. Blood samples were collected from patients on days 1, 2, 4, 6, 8, 11 and 15 and from healthy controls. Levels of PAI-1, IFN-α, IFN-γ, IL-1β, IL-6, IL-8, IL-12/IL-23p40, IL-17A, TNF-α, MCP-1, IL-4 and IL-10 were measured. SOFA, JAAM DIC and ISTH DIC scores were evaluated at the same times blood samples were taken. Network analysis revealed a network formed by PAI-1, IL-6, IL-8, MCP-1 and IL-10 on days 1, 2 and 4 throughout the acute phase of sepsis. There were positive correlations of each cytokine and the combined score (IL-6 + IL-8 + IL-10 + MCP-1) with the SOFA, JAAM DIC and ISTH DIC scores throughout the acute phase. A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.

• Authors: Hisatake Matsumoto, Hiroshi Ogura, Kentaro Shimizu, Mitsunori Ikeda, Tomoya Hirose, Hiroshi Matsuura, Sujin Kang, Kanae Takahashi, Toshio Tanaka, Takeshi Shimazu
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 13995 (09 18 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30228372 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Cytokines

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Case-Control Studies
• Cytokines (blood)
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• ROC Curve
• Sepsis (blood, pathology)
• Severity of Illness Index
• Survival Rate