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Targeted delivery of adenosine 5'-triphosphate using chitosan-coated mesoporous hydroxyapatite: A theranostic pH-sensitive nanoplatform with enhanced anti-cancer effect.

Abstract
In this Study, a pH-sensitive nanoplatform made up of chitosan (Cs) and mesoporous hydroxyapatite (HAP) was synthesized and employed for delivering of adenosine 5'-triphosphate (ATP). The fabricated system was decorated with folic acid (FA), providing both tumor targeting and imaging. The FA.Cs.ATP@HAP nanoparticles displayed enhanced colloidal stability and controlled drug release. In vitro biological experiments revealed that FA.Cs.ATP@HAP was internalized into the tumor cells with a high efficiency in a time-dependent manner and exhibited strong fluorescence within the cells. Compared with free ATP, the FA.Cs.ATP@HAP nanoparticles exhibited a significant inhibition effect against the proliferation of the tumor cells (Saos-2, T47D, and MCF7) in a dose-dependent manner, while no significant cytotoxic effect was observed in the normal cells (HEK-293), indicating the selective cytotoxicity of the fabricated nanosystem against the tumor cells. Also, the mechanism of action of FA.Cs.ATP@HAP was investigated, and it was found that it induces a high rate of apoptosis in the tumor cells through a decrease in mitochondrial membrane potential and caspase activation. Based on these findings, FA.Cs.ATP@HAP is a novel biomedical material with targeting, imaging, and high anticancer properties against tumor cells, and it could be considered as a promising candidate for cancer therapy.
AuthorsMohadeseh S Feiz, Azadeh Meshkini
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 129 Pg. 1090-1102 (May 15 2019) ISSN: 1879-0003 [Electronic] Netherlands
PMID30170062 (Publication Type: Journal Article)
CopyrightCopyright © 2018 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Adenosine Triphosphate
  • Chitosan
  • Durapatite
Topics
  • Adenosine Triphosphate (chemistry, metabolism, pharmacology)
  • Adsorption
  • Antineoplastic Agents (chemistry, metabolism, pharmacology)
  • Biological Transport
  • Cell Line, Tumor
  • Chitosan (chemistry)
  • Drug Carriers (chemistry)
  • Durapatite (chemistry)
  • Humans
  • Hydrogen-Ion Concentration
  • Kinetics
  • Nanoparticles (chemistry)
  • Porosity
  • Surface Properties
  • Theranostic Nanomedicine

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