Redox-responsive self-assembly PEG nanoparticle enhanced triptolide for efficient antitumor treatment.

Abstract

Chemotherapy induces tumor cell death by directly damaging DNA or hindering cell mitosis. Some of the drawbacks of most chemotherapy are lack of target selectivity to tumor cells, and adverse drug reaction, which limit the treatment intensity and frequency. Herein, we synthesized the prodrug of triptolide (TP) coupled to vitamin E (VE) using dithiodiglycolic acid and co-dissolved with PEG2000- linoleic acid (MPEG200-LD) in ethanol. The PEGylated TP prodrug self-assembly nanoparticles (PTPPSN) were prepared via nanoprecipitation method. Besides, characterization, stability and in vitro release of the PEGylated nanometer prodrug were investigated. Furthermore, in vitro and in vivo antitumor efficacy of PTPPSN explored showed that the cytotoxicity of triptolide was significantly reduced in vitro preparation. However, in vitro and in vivo antitumor effect of PTPPSN was significantly improved compared to the original triptolide. In summary, the PEGylated nanoparticle successfully encapsulated triptolide yielded suitable cell microenvironment, and nanotechnology-related achievements. This study, therefore, provides a new method for antitumor research as well as an innovative technology for clinical treatment of malignant tumor.

• Authors: Yanchun Wang, Xuewei Liu, Xuemei Wang, Wei Zheng, Junping Zhang, Feng Shi, Junbao Liu
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 12968 (08 28 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30154488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diterpenes
• Drug Carriers
• Epoxy Compounds
• Phenanthrenes
• Prodrugs
• triptolide
• Polyethylene Glycols

Topics

• Animals
• Cell Line, Tumor
• Diterpenes (chemistry, pharmacokinetics, pharmacology)
• Drug Carriers (chemistry, pharmacokinetics, pharmacology)
• Epoxy Compounds (chemistry, pharmacokinetics, pharmacology)
• Mice
• Nanoparticles (chemistry, therapeutic use)
• Neoplasms, Experimental (drug therapy, metabolism, pathology)
• Phenanthrenes (chemistry, pharmacokinetics, pharmacology)
• Polyethylene Glycols (chemistry, pharmacokinetics, pharmacology)
• Prodrugs (chemistry, pharmacokinetics, pharmacology)