Abstract | OBJECTIVES: DESIGN: Secondary analysis of data collected prospectively by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. SETTING: Three Collaborative Pediatric Critical Care Research Network-affiliated hospitals. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:
Hemolysis was defined based on peak plasma free hemoglobin levels during extracorporeal membrane oxygenation and categorized as none (< 0.001 g/L), mild (0.001 to < 0.5 g/L), moderate (0.5 to < 1.0 g/L), or severe (≥ 1.0 g/L). Of 216 patients, four (1.9%) had no hemolysis, 67 (31.0%) had mild, 51 (23.6%) had moderate, and 94 (43.5%) had severe. On multivariable analysis, variables independently associated with higher daily plasma free hemoglobin concentration included the use of in-line hemofiltration or other continuous renal replacement therapy, higher hemoglobin concentration, higher total bilirubin concentration, lower mean heparin infusion dose, lower body weight, and lower platelet count. Using multivariable Cox modeling, daily plasma free hemoglobin was independently associated with development of renal failure during extracorporeal membrane oxygenation (defined as creatinine > 2 mg/dL [> 176.8 μmol/L] or use of in-line hemofiltration or continuous renal replacement therapy) (hazard ratio, 1.04; 95% CI, 1.02-1.06; p < 0.001), but not mortality (hazard ratio, 1.01; 95% CI, 0.99-1.04; p = 0.389). CONCLUSIONS:
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Authors | Heidi J Dalton, Katherine Cashen, Ron W Reeder, Robert A Berg, Thomas P Shanley, Christopher J L Newth, Murray M Pollack, David Wessel, Joseph Carcillo, Rick Harrison, J Michael Dean, Kathleen L Meert, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 19
Issue 11
Pg. 1067-1076
(Nov 2018)
ISSN: 1529-7535 [Print] United States |
PMID | 30106767
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adolescent
- Anticoagulants
(administration & dosage)
- Child
- Child, Preschool
- Extracorporeal Membrane Oxygenation
(adverse effects, methods)
- Female
- Hemofiltration
(adverse effects)
- Hemolysis
- Heparin
(administration & dosage)
- Humans
- Infant
- Infant, Newborn
- Male
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Severity of Illness Index
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