Protective effects of α-bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol-induced myocardial infarction: In vivo and in vitro evidences.
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| Abstract |
The effect of α-bisabolol on hemodyanimcs, lipid peroxidation, and nonenzymatic antioxidants was evaluated in isoproterenol-induced myocardial infarction in rats. They were pre- and cotreated with α-bisabolol (25 mg/kg body weight) daily for 10 days along with the subcutaneous injection of isoproterenol (85 mg/kg body weight) at an interval of 24 hours for 2 days (9th and 10th days). Increased activities of serum creatine kinase and creatine kinase-MB along with altered levels/concentrations of lipid peroxidation products and nonenzymatic status were observed in the plasma and heart tissues of rats. Treatment with α-bisabolol showed protective effects by reversing the altered biochemical parameters and hemodynamics studied. The in vitro reducing power of α-bisabolol confirmed its potent antioxidant action. These biochemical benefits were translated into functional recovery by the maintenance of the hemodynamics in rats. The findings showed that α-bisabolol has the potential to protect against isoproterenol-induced myocardial infarction due to its potent antilipid peroxidation and antioxidant properties.
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| Authors | Mohamed Fizur Nagoor Meeran, Farah Laham, Hasan Al-Taee, Sheikh Azimullah, Shreesh Ojha |
| Journal | Journal of biochemical and molecular toxicology (J Biochem Mol Toxicol) Vol. 32 Issue 10 Pg. e22200 (Oct 2018) ISSN: 1099-0461 [Electronic] United States |
| PMID | 30088836 (Publication Type: Journal Article) |
| Copyright | © 2018 Wiley Periodicals, Inc. |
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