Reduced incidence of cardiovascular events in hyper-Lp(a) patients on lipoprotein apheresis. The G.I.L.A. (Gruppo Interdisciplinare Aferesi Lipoproteica) pilot study.

Abstract

BACKGROUND:

Lipoprotein apheresis (LA) is the elective therapy for homozygous and other forms of Familial Hypercholesterolemia, Familial Combined Hypercholesterolemia, resistant/intolerant to lipid lowering drugs, and hyper-lipoproteinemia(a). Lipoprotein(a) [Lp(a)] has been classified as the most prevalent genetic risk factor for coronary artery disease and aortic valve stenosis.

AIM:

Our multicenter retrospective study has the aim to analyze the incidence of adverse cardiovascular events (ACVE) before and during the LA treatment, in subjects with elevated level of Lp(a) (>60 mg/dL) [hyper-Lp(a)] and chronic ischemic heart disease.

METHODS:

We collected data of 23 patients (mean age 63 ± 9 years, male 77%; from hospital of Pisa 11/23, Pistoia 7/23, Verona 2/23, Padova 2/23 and Ferrara 1/23), with hyper-Lp(a), pre-apheresis LDL-cholesterol <100 mg/dL, cardiovascular disease, on maximally tolerated lipid lowering therapy and LA treatment (median 7 years, interquartile range 3-9 years). The LA treatment was performed by heparin-induced LDL precipitation apheresis (16/23), dextran-sulphate (4/23), cascade filtration (2/23) and immunoadsorption (1/23). The time lapse between first cardiovascular event and beginning of apheresis was 6 years (interquartile range 1-12 years).

RESULTS:

The recorded ACVE, before and after the LA treatment inception, were 40 and 10 respectively (p < 0.05), notably, the AVCE rates/year were 0.43 and 0.11 respectively (p < 0.05) with a 74% reduction of event occurrence.

CONCLUSIONS:

Our data confirm long-term efficacy and positive impact of LA on morbidity in patients with hyper-Lp(a) and chronic ischemic heart disease on maximally tolerated lipid lowering therapy.

• Authors: Federico Bigazzi, Francesco Sbrana, Daniele Berretti, Zenti Maria Grazia, Sabina Zambon, Antonia Fabris, Maurizio Fonda, Giovanni B Vigna, Giovanna D'Alessandri, Stefano Passalacqua, Beatrice Dal Pino, Mascia Pianelli, Roberta Luciani, Andrea Ripoli, Daniela Rafanelli, Enzo Manzato, Luigi Cattin, Tiziana Sampietro
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 57 Issue 5 Pg. 661-664 (Oct 2018) ISSN: 1473-0502 [Print] England
• PMID: 30087087 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Lipoprotein(a)

Topics

• Aged
• Cardiovascular Diseases (genetics, metabolism)
• Humans
• Incidence
• Lipoprotein(a) (metabolism)
• Middle Aged
• Pilot Projects
• Retrospective Studies