In the present study,
Karanjin and
Pongapin, two important furanoflavone, constituents of Pongamia pinnata were studied in the management of
Psoriasis. Presently, we have experimentally studied the
free radical quenching property of
Karanjin and
Pongapin. A modified method was used to estimate the scavenging effect of the
Karanjin (the highest activity of 95.60%) and
Pongapin (68.05%) compared to the
ascorbic acid as standard (11.60%) against
nitric oxide. Furthermore, Molecular docking studies were performed using CLC
drug discovery workbench software version 3.0 of the studied
flavones (
Karanjin and
Pongapin) with the receptors responsible for
psoriasis (viz. IL-17A, IL-17F, IL-23, RORĪ³t, and TLR-7). Docking scores of
Karanjin and
Pongapin with different studied receptors were found to be comparable to that of
Methotrexate, a known
drug for treating
Psoriasis. Docking results suggest that
Karanjin and
Pongapin might also help in controlling the disease. Overall, our results indicate that
flavones (
Karanjin and
Pongapin) could be a natural and better alternative in curing
psoriasis without any side effects.