Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and Photothermal therapy.

Abstract

Tumor angiogenesis is a key step in the process of tumor development, and antitumor angiogenesis has a profound influence on tumor growth. Herein we report a dual-function drug delivery system comprising a Near-infrared (NIR) dye and an anti-angiogenic drug within liposomes (Lip-IR780-Sunitinib) for enhanced antitumor therapy. The hydrophobic NIR dye IR780 was loaded into the liposome phospholipid bilayer, and the bilayer would be disrupted by laser irradiation so that anti-angiogenic drug sunitinib release would be activated remotely at the tumor site. The released hydrophilic sunitinib could potentially target multiple VEGF receptors on the tumor endothelial cell surface to inhibit angiogenesis. Meanwhile, IR780-loaded liposomes kill the cancer cells by photothermal therapy. Lip-IR780-Sunitinib exhibited enhanced anti-tumor and anti-angiogenic effects in vitro and in vivo. This system facilitates easy and controlled release of cargos to achieve anti-tumor angiogenesis and photothermal therapy.

• Authors: Xue Yang, Huipeng Li, Chenggen Qian, Yuxin Guo, Chenzi Li, Fang Gao, Ying Yang, Kaikai Wang, David Oupicky, Minjie Sun
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 14 Issue 7 Pg. 2283-2294 (10 2018) ISSN: 1549-9642 [Electronic] United States
• PMID: 29981460 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium
• Angiogenesis Inhibitors
• Drug Carriers
• Indoles
• Liposomes
• Sunitinib

Topics

• Angiogenesis Inhibitors (chemistry, pharmacology)
• Animals
• Apoptosis
• Breast Neoplasms (pathology, therapy)
• Cell Movement
• Cell Proliferation
• Combined Modality Therapy
• Drug Carriers (chemistry)
• Drug Delivery Systems
• Female
• Humans
• Hyperthermia, Induced
• Indoles (administration & dosage, chemistry)
• Lasers
• Liposomes (administration & dosage, chemistry)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Neovascularization, Pathologic (pathology, therapy)
• Phototherapy
• Spectroscopy, Near-Infrared
• Sunitinib (chemistry, pharmacology)
• Tumor Cells, Cultured
• Xenograft Model Antitumor Assays