Abstract | BACKGROUND: Platelet activation and oxidative stress seem to play a key role in coronary thrombus formation and are associated with thrombus burden in ST-elevation myocardial infarction ( STEMI). However, the interplay between oxidative stress and platelet activation has not been fully elucidated. MATERIALS AND METHODS: RESULTS: In aspirated thrombi and blood waste of STEMI patients we found higher serum levels of sNox2-dp, oxLDLs, sCD40L, and sP- selectin, as compared to the intracoronary blood samples of SA patients. Moreover, in thrombi and blood waste of STEMI patients, a direct correlation between markers of oxidative stress and of platelet activation was found. Also, in STEMI patients a progressive increase of oxidative stress and platelet activation markers was observed according to the thrombus score burden. STEMI patients showed higher peripheral blood Nox2 activity and oxLDL levels as compared to SA patients. CONCLUSION: This study shows a close relationship between oxidative stress and platelet activation in the intracoronary blood waste and aspirated thrombi of STEMI patients, suggesting a role of oxidative stress in promoting thrombus formation and growth.
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Authors | Camilla Calvieri, Gaetano Tanzilli, Simona Bartimoccia, Roberto Cangemi, Alessio Arrivi, Marcello Dominici, Vittoria Cammisotto, Nicola Viceconte, Enrico Mangieri, Giacomo Frati, Francesco Violi |
Journal | Antioxidants (Basel, Switzerland)
(Antioxidants (Basel))
Vol. 7
Issue 7
(Jul 03 2018)
ISSN: 2076-3921 [Print] Switzerland |
PMID | 29970802
(Publication Type: Journal Article)
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