High Consumption of Green Tea Suppresses Urinary Tract Recurrence of Urothelial Cancer via Down-regulation of Human Antigen-R Expression in Never Smokers.

Abstract

BACKGROUND/AIM:

Smoking is a risk factor for carcinogenesis and progression of urothelial cancer (UC). Green tea polyphenol inhibits these malignant behaviors and suppresses human antigen R (HuR) expression, which is associated with malignant aggressiveness. This study aimed to clarify the anti-cancer effects of green tea based on the smoking status of UC patients.

PATIENTS AND METHODS:

Three hundred and sixty (260 with bladder cancer, BC and 100 with upper tract UC) patients were divided into three groups based on consumption of green tea: low (<1 cup/day, n=119), middle (1-4 cup/day, n=160), and high (>5 cup/day, n=81). HuR immunoreactivity was evaluated immunohistochemically in formalin-fixed specimens.

RESULTS:

In never smokers, multivariate analysis showed that the frequency of green tea consumption was a significant predictor (middle: hazard ratio, HR, 0.36, p=0.002; high: HR, 0.20, p=0.003) of urinary tract recurrence. A high consumption of green tea was associated with low rates of urinary tract recurrence and up-grading in UC patients. In BC, high consumption was associated with a lower risk of up-grading (p=0.011) and up-staging (p=0.041) in recurrent cancer. HuR expression in the high-consumption group was lower (p=0.019) than that in other groups. These significant findings were not detected in ever smokers.

CONCLUSION:

High consumption of green tea suppressed urinary tract recurrence and the risks of up-grading and up-staging by recurrence in never smokers. Our results suggested that HuR expression played important roles in such mechanisms.

• Authors: Takuji Yasuda, Yasuyoshi Miyata, Yuichiro Nakamura, Yuji Sagara, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
• Journal: In vivo (Athens, Greece) (In Vivo) 2018 Jul-Aug Vol. 32 Issue 4 Pg. 721-729 ISSN: 1791-7549 [Electronic] Greece
• PMID: 29936451 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Polyphenols
• Receptors, Antigen
• Tea

Topics

• Adult
• Aged
• Female
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diet therapy, genetics, pathology)
• Polyphenols (administration & dosage, chemistry)
• Receptors, Antigen (genetics)
• Risk Factors
• Smokers
• Tea (chemistry)
• Urinary Bladder Neoplasms (diet therapy, genetics, pathology)
• Urinary Tract (drug effects, pathology)
• Urologic Neoplasms (diet therapy, genetics, pathology)
• Urothelium (drug effects, pathology)