Abstract | BACKGROUND: CASE PRESENTATION: We report a 55-year-old postmenopausal woman experienced vaginal spotting for one month, and serum level of AFP was 60,721 ng/ml initially. Histological examination was clear cell type EOC. Tumor cells revealed strong immunoreactivity for glypican-3 (GPC3) and AFP and weak for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO (International Federation of Gynecology and Obstetrics) IIIc. Although the patient underwent an intensive treatment, including optimal debulking surgery and multi-agent chemotherapy, the patient died of disease. To provide a better understanding of clinical and molecular characteristics of the AFP-producing clear cell type EOC, we conducted a systematic literature review. CONCLUSIONS: A total of three papers described the AFP-producing clear cell type EOC are available. The overall survival rate of these cases, including the current case is 50%. Although immunohistochemical examination is not always needed in routine for the diagnosis of clear cell type EOC, to distinguish from other tumors, especially germ cell tumors, or to provide the better way to monitor therapeutic response or to evaluate the disease status, immunostaining, including GPC3, HNF-1 beta, CD30, cytokeratin 7 or 20, and AFP is taken into account. Due to rarity, the appropriate chemotherapy regimen and the biological behavior of AFP-producing clear cell type EOC are still unclear.
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Authors | Wei-Ting Chao, Chia-Hao Liu, Chiung-Ru Lai, Yi-Jen Chen, Chi-Mu Chuang, Peng-Hui Wang |
Journal | Journal of ovarian research
(J Ovarian Res)
Vol. 11
Issue 1
Pg. 52
(Jun 22 2018)
ISSN: 1757-2215 [Electronic] England |
PMID | 29933751
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- GPC3 protein, human
- Glypicans
- Neoplasm Proteins
- alpha-Fetoproteins
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Topics |
- Adenocarcinoma, Clear Cell
(blood, genetics, pathology)
- Biomarkers, Tumor
(blood)
- Cell Differentiation
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
- Glypicans
(blood)
- Humans
- Immunohistochemistry
- Middle Aged
- Neoplasm Proteins
(genetics)
- Ovarian Neoplasms
(blood, pathology)
- alpha-Fetoproteins
(metabolism)
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