Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.

Abstract

For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hydrolase activity: (S)-9-(2,3-dihydroxypropyl)adenine less than (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) less than carbocyclic 3-deazaadenosine less than neplanocin A. Our findings point to AdoHcy hydrolase as the target for the broad-spectrum antiviral activity of these adenosine analogues.

• Authors: E De Clercq, M Cools
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 129 Issue 1 Pg. 306-11 (May 31 1985) ISSN: 0006-291X [Print] United States
• PMID: 2988550 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Antiviral Agents
• 9-(2,3-dihydroxypropyl)adenine
• neplanocin A
• carbocyclic 3-deazaadenosine
• 3-adenin-9-yl-2-hydroxypropanoic acid
• Hydrolases
• Adenosylhomocysteinase
• Adenine
• Adenosine
• Tubercidin

Topics

• Adenine (analogs & derivatives, pharmacology)
• Adenosine (analogs & derivatives, pharmacology)
• Adenosylhomocysteinase
• Antibiotics, Antineoplastic (pharmacology)
• Antiviral Agents
• Hydrolases (antagonists & inhibitors)
• Kinetics
• Measles virus (physiology)
• Reoviridae (physiology)
• Tubercidin (analogs & derivatives, pharmacology)
• Vaccinia virus (physiology)
• Vesicular stomatitis Indiana virus (physiology)
• Virus Replication (drug effects)